SUBSTITUTED PTERIDINONES, PYRIMIDINES, PYRROLOPYRIMIDINES, AND PURINES AS P90 RIBOSOMAL S6 PROTEIN KINASE-2 (RSK2) INHIBITORS: PHARMACOPHORE MODELING DATA

The RSK2 kinase is a downstream effector of the Ras/Raf/MEK/ERK pathway that is aberrantly active in a range of cancer types and has been recognized an anticancer target.The inhibition of RSK2 kinase activity would disrupt multiple pro-cancer processes; however, there are few RSK2 inhibitors.The data have been obtained for a series of pteridinone-,

A cardinal feature of malignant melanoma is its metastatic propensity.An incomplete view of the genetic events driving metastatic progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for melanoma patients.In this study, we conducted global genomic characterization of primary and metastati

The rule of immunity of states and their property from the jurisdiction of domestic courts is a rule of customary international law and exceptions are set out Creator T-Shirt in customary international law as well as in the 2004 United Nations Convention on Immunity but some countries, such as Canada, have begun efforts to add a new exception calle

The purpose of the present study is to review and analyze how much attention is paid to the criteria of moral education in the Persian books in ProSeries Lighting Parts elementary schools.The method of study is categorical content analysis, and the units under analysis include texts, poems, and images.Statistical population of the research is compo

Abstract Burkholderia terrae BS001 has previously been found to be able to disperse along with growing fungal hyphae in soil, with the type-3 secretion system Creator T-Shirt having a supportive role in this movement.In this study, we focus on the role of two motility- and adherence-associated appendages, i.e.type-4 pili (T4P) and flagella.Electron